Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380902 | 0.86 | MKNK1 (0.55) | AURKAMKNK1MKNK2PIK3CAMTOR | |
| SCHEMBL6479199 | 0.85 | PIK3CA (0.52) | AURKAPIK3CAMTORCHEK1MAP3K7 | |
| SCHEMBL14380901 | 0.80 | MKNK1 (0.69) | AURKAMKNK1MKNK2CDK2JAK2 | |
| SCHEMBL6485821 | 0.77 | PIK3CA (0.52) | AURKAPIK3CAMTORCHEK1MAP3K7 | |
| SCHEMBL14380908 | 0.73 | MAPK8 (0.47) | MKNK1MKNK2JAK2CCNT1CDK9 | |
| SCHEMBL6479848 | 0.73 | PIK3CA (0.54) | PIK3CAMTORKDRLCK | |
| SCHEMBL14380858 | 0.72 | KDR (0.56) | CDK2PIK3CAJAK2KDRALK | |
| SCHEMBL14214732 | 0.71 | SCN9A (0.59) | PIK3CAMTOR | |
| SCHEMBL14380906 | 0.70 | MKNK1 (0.40) | MKNK1MKNK2CDK2PIK3CAMTOR | |
| SCHEMBL14380899 | 0.69 | MKNK1 (0.80) | MKNK1MKNK2CDK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |