Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14380904 | 0.83 | PIK3CA (0.49) | MKNK1MKNK2CDK2PYGMPIK3CA | |
| SCHEMBL7167174 | 0.79 | PYGM (0.44) | VCPCDK9DAPK3MAP4K4PRKACA | |
| SCHEMBL14380908 | 0.76 | MAPK8 (0.47) | MKNK1MKNK2MAPK10CDK9MAPK8 | |
| SCHEMBL14380901 | 0.74 | MKNK1 (0.69) | MKNK1MKNK2MAPK10MAPK8AURKB | |
| SCHEMBL14380892 | 0.74 | CCNT1 (0.35) | MKNK1MKNK2MAPK10CDK9CDK2 | |
| SCHEMBL11097221 | 0.73 | CSNK1A1 (0.61) | VCPMKNK2CDK9DAPK3MAP4K4 | |
| SCHEMBL14380902 | 0.73 | MKNK1 (0.55) | MKNK1MKNK2PIK3CAMTOR | |
| SCHEMBL14380858 | 0.73 | KDR (0.56) | ALKCDK2PIK3CALCK | |
| SCHEMBL7018086 | 0.72 | LCK (0.65) | LCK | |
| SCHEMBL14380920 | 0.72 | RPS6KA5 (0.48) | NOS2CYP1A2CYP2D6HTTCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-7282504-B2 | Kinase inhibitors | AMGEN INC. (US) | 2007-10-16 | — | — | US | disclosed |