Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | PRKACA | P17612 | 1/20 | 0.61 |
| ▸ | LTK | P29376 | 1/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.61 |
| ▸ | CDK8 | P49336 | 1/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.61 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10981062 | 0.81 | MAPK1 (0.54) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL6836635 | 0.75 | ALDH1A1 (0.52) | CDK5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6836632 | 0.75 | ALDH1A1 (0.52) | CDK5KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7294885 | 0.74 | PDPK1 (0.44) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL7167174 | 0.74 | PYGM (0.44) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL7764042 | 0.74 | METAP2 (0.58) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL4870334 | 0.73 | KDM4E (0.49) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL14380906 | 0.73 | MKNK1 (0.40) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL1977322 | 0.72 | NOS2 (0.50) | CSNK1A1CLK2CLK4LIMK1DYRK1B | |
| SCHEMBL7165417 | 0.72 | JAK2 (0.68) | CSNK1A1CLK2CLK4AURKBALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434288-A | Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles | ELI LILLY AND COMPANY (US) | 1984-02-28 | — | — | US | disclosed |