Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.43 |
| ▸ | THRA | P10827 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AGBL2 | Q5U5Z8 | 2/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877436 | 0.79 | HCAR2 (0.52) | THRBTHRAAGBL2GABRR1KDM4E | |
| Hydrochloric Acid SCHEMBL1371875 | 0.78 | HCAR2 (0.50) | THRBTHRAAGBL2GABRR1KDM4E | |
| SCHEMBL4280733 | 0.78 | ALDH1A1 (0.35) | THRBTHRAKDM4EPOLBALDH1A1 | |
| SCHEMBL8481019 | 0.77 | GRIN2D (0.37) | LMNAPOLBSLC5A2GRIN2DGRIN3B | |
| SCHEMBL24968908 | 0.75 | TIPARP (0.43) | THRBTHRALMNAAGBL2 | |
| SCHEMBL8478938 | 0.74 | BACE1 (0.40) | LMNAKDM4EALDH1A1SLC5A2GRIN2D | |
| SCHEMBL5989046 | 0.73 | HCAR2 (0.37) | THRBTHRALMNAGABRR1KDM4E | |
| SCHEMBL1194422 | 0.72 | DAO (0.54) | POLBALDH1A1SLC5A2DAOHCAR2 | |
| SCHEMBL3267501 | 0.72 | LMNA (0.38) | THRBTHRALMNAPOLBALDH1A1 | |
| SCHEMBL1592992 | 0.72 | GABRA5 (0.43) | THRBTHRALMNAGABRR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7291729-B2 | Process for preparing 3-aryloxy-phenylacetic acid compounds | ROCHE PALO ALTO LLC (US) | 2007-11-06 | — | — | US | disclosed |