Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 8/20 | 0.36 |
| ▸ | THRA | P10827 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLEC | Q15149 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14387809 | 0.72 | THRB (0.43) | LMNATHRBTHRAPOLBMAPT | |
| SCHEMBL1195823 | 0.71 | CYP2C19 (0.41) | PTGDRPTGDR2 | |
| SCHEMBL28532363 | 0.69 | PTGDR (0.42) | LMNAPTGDRPTGDR2MEN1POLB | |
| SCHEMBL24968908 | 0.69 | TIPARP (0.43) | LMNATHRBTHRA | |
| SCHEMBL5989046 | 0.68 | HCAR2 (0.37) | LMNATHRBTHRAPOLBMAPT | |
| SCHEMBL1525313 | 0.67 | LMNA (0.47) | LMNATHRBTHRAMEN1POLB | |
| SCHEMBL10429633 | 0.67 | TP53 (0.43) | — | |
| SCHEMBL877436 | 0.66 | HCAR2 (0.52) | THRBTHRAMEN1POLBMAPT | |
| SCHEMBL1592992 | 0.66 | GABRA5 (0.43) | LMNATHRBTHRAMEN1POLB | |
| Hydrochloric Acid SCHEMBL1371875 | 0.65 | HCAR2 (0.50) | THRBTHRAMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164835-B1 | PROCESS FOR PREPARING TRIAZOLONES | HOFFMANN LA ROCHE (CH) | 2012-12-12 | — | — | EP | disclosed |
| US-20100280256-A1 | PROCESS FOR PREPARING TRIAZOLONES | LEE GARY M | 2010-11-04 | — | — | US | disclosed |
| US-7745634-B2 | Process for preparing triazolones | ROCHE PALO ALTO LLC (US) | 2010-06-29 | — | — | US | disclosed |
| EP-2164835-A2 | PROCESS FOR PREPARING TRIAZOLONES | F. Hoffmann-Roche AG (CH) | 2010-03-24 | — | — | EP | disclosed |
| US-20090012304-A1 | preparation of intermediates 3-[3-(4-methyl-5-methylsulfanyl-4H-[1,2,4]triazol-3-ylmethyl)phenoxy]-5-difluoromethyl-benzonitrile derivatives; for making enzyme inhibitors of HIV-1 reverse transcriptase, treating AIDS and HIV-1 syndromes | ROCHE PALO ALTO LLC | 2009-01-08 | — | — | US | disclosed |
| WO-2008145563-A2 | PROCESS FOR PREPARING TRIAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280256-A1 | PROCESS FOR PREPARING TRIAZOLONES | CYP51A1, TNKS, TNKS2 | LMNA 1727/4885PTGDR 2511/4885PTGDR2 2693/4885 |
| US-20090012304-A1 | preparation of intermediates 3-[3-(4-methyl-5-methylsulfanyl-4H-[1,2,4]triazol-3-ylmethyl)phenoxy]-5-difluoromethyl-benzonitrile derivatives; for making enzyme inhibitors of HIV-1 reverse transcriptase, treating AIDS and HIV-1 syndromes | POLRMT, TYMS, POLR1G | LMNA 2424/4885PTGDR 4318/4885PTGDR2 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.