Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.47 |
| ▸ | SRC | P12931 | 7/20 | 0.46 |
| ▸ | LCK | P06239 | 6/20 | 0.46 |
| ▸ | YES1 | P07947 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 2/20 | 0.46 |
| ▸ | GAK | O14976 | 2/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.46 |
| ▸ | MAP3K13 | O43283 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142205 | 0.85 | KDR (0.51) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL176013 | 0.85 | MET (0.58) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL144281 | 0.83 | KDR (0.68) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL146016 | 0.78 | FGFR1 (0.64) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL142850 | 0.73 | KDR (0.66) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL144930 | 0.73 | MET (0.62) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL145369 | 0.72 | KDR (0.56) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL147096 | 0.72 | KDR (0.69) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL144979 | 0.72 | KDR (0.71) | METKDRFGFR1PDGFRBSRC | |
| SCHEMBL29689641 | 0.71 | SRC (0.74) | METKDRFGFR1PDGFRBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | claimed |
| US-20140221455-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | Verva Pharmaceuticals, Inc. (AU) | 2014-08-07 | — | — | US | disclosed |
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | VERVA PHARMACEUTICALS PTY LTD (AU) | 2012-03-08 | — | — | US | disclosed |
| US-20050282733-A1 | Differentiation modulating agents and uses therefor | VERVA PHARMACEUTICALS PTY LTD (AU) | 2005-12-22 | — | — | US | disclosed |
| WO-2005065686-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | ADIPOGEN PHARMACEUTICALS PTY LIMITED (AU) | 2005-07-21 | — | — | WO | disclosed |
| US-6599902-B2 | For treating or preventing a protein kinase related disorder | SUGEN, INC. | 2003-07-29 | — | — | US | disclosed |
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120059047-A1 | DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR | FGF1, FABP4, FGF2 | MET 310/4885KDR 1077/4885FGFR1 5/4885 |
| US-20050282733-A1 | Differentiation modulating agents and uses therefor | FGF1, FABP4, FGF2 | MET 310/4885KDR 1077/4885FGFR1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.