Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 13/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14391089 | 0.81 | MAPT (0.46) | DYRK1ACDK2WNT1MAPTMAPK1 | |
| SCHEMBL14391270 | 0.81 | MAPT (0.46) | DYRK1AWNT1MAPTMAPK1 | |
| SCHEMBL5047046 | 0.81 | CDK2 (0.42) | DYRK1ACDK2GSK3AWNT1 | |
| SCHEMBL1176497 | 0.81 | CDK2 (0.42) | DYRK1ACDK2GSK3AWNT1 | |
| SCHEMBL14390881 | 0.80 | GSK3B (0.55) | DYRK1AWNT1MAPTMAPK1 | |
| SCHEMBL14391091 | 0.79 | HAO1 (0.43) | DYRK1AWNT1MAPTMAPK1 | |
| Formic Acid SCHEMBL5561803 | 0.79 | CDK2 (0.40) | DYRK1ACDK2GSK3AWNT1 | |
| SCHEMBL14128895 | 0.77 | CDK2 (0.43) | DYRK1ACDK2GSK3AWNT1 | |
| SCHEMBL5044511 | 0.74 | CDK2 (0.48) | CDK2GSK3A | |
| SCHEMBL1176625 | 0.74 | CDK2 (0.48) | CDK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | disclosed |