⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL545938 | 0.76 | — | — | |
| SCHEMBL2042092 | 0.74 | — | — | |
| SCHEMBL3148463 | 0.70 | — | — | |
| SCHEMBL3148368 | 0.70 | — | — | |
| SCHEMBL3152083 | 0.70 | — | — | |
| SCHEMBL545786 | 0.70 | HKDC1 (0.33) | — | |
| SCHEMBL438847 | 0.70 | EEF2K (0.30) | — | |
| SCHEMBL3138242 | 0.70 | — | — | |
| SCHEMBL16497502 | 0.65 | — | — | |
| SCHEMBL442765 | 0.65 | PIM1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1615 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566042-B2 | Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds | ZATA Pharmaceuticals, Inc (US) | 2023-01-31 | — | — | US | claimed |
| US-11530181-B2 | IL-6 inhibitors and methods of treatment | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-12-20 | — | — | US | claimed |
| EP-2388003-B1 | Colchicine derivatives | CALIFORNIA PACIFIC MEDICAL CENTER (US) | 2021-12-29 | — | — | EP | claimed |
| EP-3350191-B9 | NUCLEOTIDE ANALOGS | UNIV CALIFORNIA (US) | 2021-12-22 | — | — | EP | claimed |
| US-11142545-B2 | Synthesis of thiolated oligonucleotides without a capping step | BIOGEN MA INC. (US) | 2021-10-12 | — | — | US | claimed |
| EP-3875462-A1 | NUCLEOTIDE ANALOGS | The Regents of The University of California (US) | 2021-09-08 | — | — | EP | claimed |
| US-11078227-B2 | 5′-cyclo-phosphonate modified nucleotides | Arrowhead Pharmaceuticals, Inc. (US) | 2021-08-03 | — | — | US | claimed |
| US-11072624-B2 | Synthesis of nucleoside 5′-triphosphates and their derivatives | SENA RESEARCH, INCORPORATED (US) | 2021-07-27 | — | — | US | claimed |
| EP-3350191-B1 | NUCLEOTIDE ANALOGS | UNIV CALIFORNIA (US) | 2021-05-12 | — | — | EP | claimed |
| US-10961269-B2 | Bridged nucleic acid GuNA, method for producing same, and intermediate compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2021-03-30 | — | — | US | claimed |
| EP-0354246-A1 | 5'-Phosphonates of 3'-azido-2',3'-dideoxynucleosides | INSTITUT MOLEKULYARNOI BIOLOGII IMENI V.A. ENGELGARDTA AKADEMII NAUK SSSR (SU) | 1990-02-14 | — | — | EP | claimed |
| EP-0339842-A2 | Novel oligoribonucleotide derivatives and application thereof to antiviral agents | ISIS PHARMACEUTICALS, INC. (US) | 1989-11-02 | — | — | EP | claimed |
| US-4789737-A | PROTECTED AMINO ALKYLENE GROUPS ON THE 5'-NUCLEOTIDE END; PROTECTED 3'-HYDROXYL POSITION; CARRIERS; CHROMATOGRAPHY; ADSORBERS | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1988-12-06 | — | — | US | claimed |
| EP-0136543-B1 | METHOD FOR THE PREPARATION OF NUCLEOSIDEALKYL, ARALKYL AND ARYL PHOSPHONITES AND PHOSPHONATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-11-23 | — | — | EP | claimed |
| EP-0253412-A2 | N-Phosphonylmethoxyalkyl derivatives of pyrimidine and purine bases, methods for their preparation and pharmaceutical compositions therefrom with antiviral activity | Ceskoslovenska akademie ved (CS) | 1988-01-20 | — | — | EP | claimed |
| EP-0229053-A1 | METHOD FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES | UNIVERSITY PATENTS, INC. (US) | 1987-07-22 | — | — | EP | claimed |
| WO-1986007362-A1 | METHOD FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES | UNIVERSITY PATENTS, INC. (US) | 1986-12-18 | — | — | WO | claimed |
| EP-0136543-A2 | Method for the preparation of nucleosidealkyl, aralkyl and aryl phosphonites and phosphonates | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-10 | — | — | EP | claimed |
| US-4474947-A | Benzazolides and their employment in phosphate ester oligonucleotide synthesis processes | BIOSEARCH (US) | 1984-10-02 | — | — | US | claimed |
| US-4474948-A | Benzazolides and their employment in phosphite ester oligonucleotide synthesis processes | BIOSEARCH (US) | 1984-10-02 | — | — | US | claimed |