Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2047014 | 0.73 | — | — | |
| SCHEMBL3148463 | 0.65 | — | — | |
| SCHEMBL143917 | 0.65 | — | — | |
| SCHEMBL3148368 | 0.65 | — | — | |
| SCHEMBL440393 | 0.65 | — | — | |
| SCHEMBL438847 | 0.65 | EEF2K (0.30) | — | |
| SCHEMBL2042402 | 0.64 | CES1 (0.32) | PIM1PIM2 | |
| SCHEMBL8554982 | 0.62 | — | — | |
| SCHEMBL8552885 | 0.61 | — | — | |
| SCHEMBL545786 | 0.61 | HKDC1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076310-B2 | Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production | K.U.LEUVEN RESEARCH & DEVELOPMENT (BE) | 2011-12-13 | — | — | US | claimed |
| EP-0719273-B1 | NUCLEOTIDE ANALOGS | GILEAD SCIENCES INC (US) | 2010-11-03 | — | — | EP | claimed |
| US-20100087387-A1 | FIVE- AND SIX-MEMBERED CONFORMATIONALLY LOCKED 2',4'-CARBOCYCLIC RIBO-THYMIDINES FOR THE TREATMENT OF INFECTIONS AND CANCER | CHATTOPADHYAYA JYOTI | 2010-04-08 | — | — | US | claimed |
| US-7687500-B2 | Substituted oxetanes, method of making, and method of use thereof | THE UNIVERSITY OF CONNECTICUT (US) | 2010-03-30 | — | — | US | claimed |
| EP-2134736-A1 | FIVE- AND SIX-MEMBERED CONFORMATIONALLY LOCKED 2',4'- CARBOCYCLIC RIBO-THYMIDINES FOR THE TREATMENT OF INFECTIONS AND CANCER | Chattopadhyaya, Jyoti (SE) | 2009-12-23 | — | — | EP | claimed |
| WO-2008111908-A1 | FIVE- AND SIX-MEMBERED CONFORMATIONALLY LOCKED 2',4'- CARBOCYCLIC RIBO-THYMIDINES FOR THE TREATMENT OF INFECTIONS AND CANCER | CHATTOPADHYAYA JYOTI (SE) | 2008-09-18 | — | — | WO | claimed |
| US-20080139566-A1 | SUBSTITUTED OXETANES, METHOD OF MAKING, AND METHOD OF USE THEREOF | HOWELL AMY R | 2008-06-12 | — | — | US | claimed |
| JP-2007512358-A | — | — | 2007-05-17 | — | — | JP | claimed |
| EP-1685127-A1 | HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES | The University of Connecticut (US) | 2006-08-02 | — | — | EP | claimed |
| US-20050215568-A1 | Substituted oxetanes, method of making, and method of use thereof | UNIVERSITY OF CONNECTICUT, THE | 2005-09-29 | — | — | US | claimed |
| WO-2005051944-A1 | HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2005-06-09 | — | — | WO | claimed |
| WO-2004106350-A1 | NUCLEOSIDE ANALOGS AS VIRAL POLYMERASE INHIBITORS | BIOCRYST PHARMACEUTICAL, INC. (US) | 2004-12-09 | — | — | WO | claimed |
| US-20040242465-A1 | Nucleotide analogs | BISCHOFBERGER NORBERT W (US) | 2004-12-02 | — | — | US | claimed |
| US-20040014722-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | claimed |
| US-20010041794-A1 | Nucleotide analogs | GILEAD SCIENCES, INC. | 2001-11-15 | — | — | US | claimed |
| US-6225460-B1 | PHOSPHOAMIDATE OR ESTER BOND THAT IS HYDROLYZED IN VIVO TO YIELD A CORRESPONDING PHOSPHONATE NUCLEOTIDE ANALOG. | GILEAD SCIENCES, INC. | 2001-05-01 | — | — | US | claimed |
| US-5656745-A | AMIDATE LINKAGE; ANTITUMOR, ANTICARCINOGENIC AGENTS | GILEAD SCIENCES, INC. (US) | 1997-08-12 | — | — | US | claimed |
| US-20230143643-A1 | LOW DK COPPER CLAD LAMINATE COMPOSITIONS | DESIGNER MOLECULES INC (US) | 2023-05-11 | — | — | US | disclosed |
| US-4704392-A | VIRICIDES | SYNTEX (U.S.A.) INC. (US) | 1987-11-03 | — | — | US | disclosed |
| US-4605659-A | HERPES; HEPATITUS | SYNTEX (U.S.A.) INC. (US) | 1986-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242465-A1 | Nucleotide analogs | PNP, NUDT1, TYMP | PIM1 3747/4885PIM2 4093/4885 |
| US-20010041794-A1 | Nucleotide analogs | PNP, NUDT1, TYMP | PIM1 3747/4885PIM2 4093/4885 |
| US-20080139566-A1 | SUBSTITUTED OXETANES, METHOD OF MAKING, AND METHOD OF USE THEREOF | PNP, TYMP, DHPS | PIM1 931/4885PIM2 1699/4885 |
| US-20040014722-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | NSUN2, POLR2H, NSUN3 | PIM1 2311/4885PIM2 1987/4885 |
| US-20050215568-A1 | Substituted oxetanes, method of making, and method of use thereof | PNP, TYMP, DHPS | PIM1 931/4885PIM2 1699/4885 |
| US-20100087387-A1 | FIVE- AND SIX-MEMBERED CONFORMATIONALLY LOCKED 2',4'-CARBOCYCLIC RIBO-THYMIDINES FOR THE TREATMENT OF INFECTIONS AND CANCER | TYMS, NSUN2, RNMT | PIM1 3573/4885PIM2 4108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.