Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929104 | 1.00 | LMNA (0.47) | LMNAHTTMAPTHSD17B10KDM4E | |
| SCHEMBL13815370 | 0.89 | KDM4E (0.47) | LMNAHTTMAPTHSD17B10KDM4E | |
| SCHEMBL11925210 | 0.89 | KDM4E (0.47) | LMNAHTTMAPTHSD17B10KDM4E | |
| SCHEMBL20368993 | 0.89 | KDM4E (0.44) | LMNAHTTMAPTHSD17B10KDM4E | |
| Tripamide SCHEMBL49666 | 0.87 | KDM4E (0.59) | LMNAHTTMAPTHSD17B10KDM4E | |
| Tripamide SCHEMBL1651231 | 0.87 | KDM4E (0.59) | LMNAHTTMAPTHSD17B10KDM4E | |
| Tripamide SCHEMBL4442559 | 0.74 | KDM4E (0.46) | LMNAHTTMAPTHSD17B10KDM4E | |
| Diapamide SCHEMBL119354 | 0.74 | GSTO1 (0.54) | LMNAHTTMAPTHSD17B10KDM4E | |
| Diapamide SCHEMBL27555055 | 0.74 | GSTO1 (0.54) | LMNAHTTMAPTHSD17B10KDM4E | |
| SCHEMBL11557173 | 0.73 | GSTO1 (0.55) | HTTMAPTHSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282519-B2 | Nitrosated and nitrosylated diuretic compounds, compositions and methods of use | NITROMED, INC. (US) | 2007-10-16 | — | — | US | disclosed |