Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 10/20 | 0.42 |
| ▸ | CA2 | P00918 | 10/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tripamide SCHEMBL1651231 | 0.84 | KDM4E (0.59) | KDM4ELMNAGLAMAPTHTT | |
| Tripamide SCHEMBL49666 | 0.84 | KDM4E (0.59) | KDM4ELMNAGLAMAPTHTT | |
| Torsemide SCHEMBL3230485 | 0.82 | TBXA2R (0.50) | KDM4ELMNAGLAMAPTHTT | |
| Xipamide SCHEMBL6711167 | 0.79 | CA1 (0.48) | KDM4ELMNAMAPTHTTCA1 | |
| Xipamide SCHEMBL29377965 | 0.79 | CA1 (0.48) | KDM4ELMNAMAPTHTTCA1 | |
| Xipamide SCHEMBL43532 | 0.79 | CA1 (0.48) | KDM4ELMNAMAPTHTTCA1 | |
| Indapamide SCHEMBL28086620 | 0.78 | CA1 (0.74) | KDM4ELMNAGLAMAPTHTT | |
| Xipamide SCHEMBL6898106 | 0.75 | CA12 (0.48) | CA1CA2CA12CA9CA3 | |
| SCHEMBL11929104 | 0.74 | LMNA (0.47) | KDM4ELMNAGLAMAPTHTT | |
| SCHEMBL14394547 | 0.74 | LMNA (0.47) | KDM4ELMNAGLAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210137875-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | OTOLANUM AG (CH) | 2021-05-13 | — | — | US | claimed |
| US-20180360797-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) | 2018-12-20 | — | — | US | claimed |
| US-20160271098-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) | 2016-09-22 | — | — | US | claimed |
| US-20150044200-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | OTOLANUM AG (CH) | 2015-02-12 | — | — | US | claimed |
| EP-2790686-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | Auris Medical AG (CH) | 2014-10-22 | — | — | EP | claimed |
| WO-2013087090-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | AURIS MEDICAL AG (CH) | 2013-06-20 | — | — | WO | claimed |
| US-20230404955-A1 | USE OF (1S,3S)-3-AMINO-4-(DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID IN THE TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, MENIERE’S DISEASE, TOURETTE’S SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ADDICTION | OVID THERAPEUTICS INC. | 2023-12-21 | — | — | US | disclosed |
| US-11771671-B2 | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, attention deficit hyperactivity disorder and addiction | OVID THERAPEUTICS INC. (US) | 2023-10-03 | — | — | US | disclosed |
| EP-2790686-B1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | Zilentin AG (CH) | 2021-03-10 | — | — | EP | disclosed |
| EP-3735237-A1 | USE OF (1S,3S)-3-AMINO-4-(DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID IN THE TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, MENIERE'S DISEASE, TOURETTE'S SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ADDICTION | Ovid Therapeutics Inc. (US) | 2020-11-11 | — | — | EP | disclosed |
| US-20200246293-A1 | USE OF (1S,3S)-3-AMINO-4-(DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID IN THE TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, MENIERE'S DISEASE, TOURETTE'S SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ADDICTION | OVID THERAPEUTICS INC. | 2020-08-06 | — | — | US | disclosed |
| US-10709682-B2 | Treatment of tinnitus through modulation of chloride co-transporter NKCC1 in the auditory system | OTOLANUM AG (CH) | 2020-07-14 | — | — | US | disclosed |
| US-10653652-B2 | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of tinnitus, acute sensorineural hearing loss, meniere'S disease, tourette'S syndrome, attention deficit hyperactivity disorder and addiction | OVID THERAPEUTICS INC. (US) | 2020-05-19 | — | — | US | disclosed |
| WO-2018144827-A1 | USE OF GABOXADOL IN THE TREATMENT OF TINNITUS | OVID THERAPEUTICS INC. (US) | 2018-08-09 | — | — | WO | disclosed |
| US-20160271098-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | EBERHARD-KARLS-UNIVERSITAT TUBINGEN UNIVERSITATSKLINIKUM (DE) | 2016-09-22 | — | — | US | disclosed |
| US-20150044200-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | OTOLANUM AG (CH) | 2015-02-12 | — | — | US | disclosed |
| EP-2790686-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | Auris Medical AG (CH) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013087090-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | AURIS MEDICAL AG (CH) | 2013-06-20 | — | — | WO | disclosed |
| EP-2120899-A1 | ANTIHYPERTENSIVE DRUG COMBINATION | Gilead Colorado, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008100803-A1 | ANTIHYPERTENSIVE DRUG COMBINATION | GILEAD COLORADO, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10653652-B2 | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of tinnitus, acute sensorineural hearing loss, meniere'S disease, tourette'S syndrome, attention deficit hyperactivity disorder and addiction | SLC6A3, SLC1A2, SLC1A3 | KDM4E 1780/4885LMNA 4472/4885GLA 3100/4885 |
| US-20180360797-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | SLC6A1, SLC6A11, SLC6A13 | KDM4E 3359/4885LMNA 4145/4885GLA 3923/4885 |
| US-20160271098-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | SLC6A1, SLC6A11, SLC6A13 | KDM4E 3398/4885LMNA 4170/4885GLA 3981/4885 |
| US-20200246293-A1 | USE OF (1S,3S)-3-AMINO-4-(DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID IN THE TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, MENIERE'S DISEASE, TOURETTE'S SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ADDICTION | SLC6A3, SLC1A2, SLC1A3 | KDM4E 1780/4885LMNA 4472/4885GLA 3100/4885 |
| US-20210137875-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | SLC6A1, SLC6A13, SLC6A11 | KDM4E 3327/4885LMNA 4527/4885GLA 4405/4885 |
| US-10709682-B2 | Treatment of tinnitus through modulation of chloride co-transporter NKCC1 in the auditory system | SLC6A1, SLC6A11, SLC6A13 | KDM4E 3378/4885LMNA 4122/4885GLA 3902/4885 |
| US-20230404955-A1 | USE OF (1S,3S)-3-AMINO-4-(DIFLUOROMETHYLIDENE) CYCLOPENTANE-1-CARBOXYLIC ACID AND (S)-3-AMINO-4-(DIFLUOROMETHYLENYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID IN THE TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, MENIERE’S DISEASE, TOURETTE’S SYNDROME, ATTENTION DEFICIT HYPERACTIVITY DISORDER AND ADDICTION | SLC6A3, SLC1A2, SLC1A3 | KDM4E 1661/4885LMNA 4431/4885GLA 3038/4885 |
| US-20150044200-A1 | TREATMENT OF TINNITUS THROUGH MODULATION OF CHLORIDE CO-TRANSPORTER NKCC1 IN THE AUDITORY SYSTEM | SLC6A1, SLC6A11, SLC6A13 | KDM4E 3378/4885LMNA 4122/4885GLA 3902/4885 |
| US-11771671-B2 | Use of (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid in the treatment of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, attention deficit hyperactivity disorder and addiction | SLC6A3, SLC1A2, SLC1A3 | KDM4E 1780/4885LMNA 4472/4885GLA 3100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.