Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323352 | 0.81 | ADRA2A (0.38) | HSD17B10TDP1CYP3A4ADRB2ADRA2A | |
| SCHEMBL29940963 | 0.79 | CA3 (0.40) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL11714444 | 0.79 | HSD17B10 (0.60) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL27192516 | 0.76 | KDM1A (0.40) | ALDH1A1TDP1MAPTNPSR1KDM1A | |
| SCHEMBL23557091 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TDP1CYP3A4MAPTNPSR1 | |
| SCHEMBL31357885 | 0.74 | TSHR (0.60) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL911775 | 0.74 | TSHR (0.60) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL30404053 | 0.73 | HIF1A (0.46) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL24716192 | 0.73 | ALDH1A1 (0.47) | HSD17B10TSHRHPGDALDH1A1TDP1 | |
| SCHEMBL5271664 | 0.73 | KDM1A (0.36) | HSD17B10TSHRHPGDALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |