Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14399296 | 0.81 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4543435 | 0.78 | GPR35 (0.41) | MEN1KMT2ACAMKK1CAMKK2SPR | |
| SCHEMBL10406124 | 0.78 | KMT2A (0.41) | MEN1KMT2ACAMKK1CAMKK2SPR | |
| SCHEMBL4900637 | 0.76 | AXL (0.43) | MEN1KMT2ACAMKK1CAMKK2SPR | |
| SCHEMBL15736808 | 0.76 | SPR (0.46) | MEN1KMT2ACAMKK1CAMKK2SPR | |
| SCHEMBL11277616 | 0.70 | KDR (0.44) | MEN1KMT2ACAMKK1CAMKK2SPR | |
| SCHEMBL27301289 | 0.70 | PDE4A (0.53) | ALDH1A1ADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL11086602 | 0.69 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1CSNK2A1ADORA2A | |
| SCHEMBL2881001 | 0.67 | ADORA2A (0.57) | MEN1KMT2ACAMKK1CAMKK2PDPK1 | |
| SCHEMBL30528561 | 0.67 | MEN1 (0.47) | MEN1KMT2AALDH1A1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276519-B2 | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors | WYETH (US) | 2007-10-02 | — | — | US | disclosed |