Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945034 | 0.85 | ALDH1A1 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL1561661 | 0.81 | CYP4F2 (0.44) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL2171302 | 0.79 | ALDH1A1 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL1396425 | 0.79 | ALDH1A1 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL18654174 | 0.79 | ALDH1A1 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL4187876 | 0.79 | ALOX15 (0.50) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL4318190 | 0.78 | ALOX15 (0.39) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL2485258 | 0.77 | ALOX15 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL10949469 | 0.77 | PKM (0.43) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL28388180 | 0.76 | ALOX15 (0.52) | ALOX15CYP4F2CYP4A11ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007110335-A1 | MALONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-04 | — | — | WO | disclosed |