Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562023 | 0.85 | ALDH1A1 (0.50) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL5446995 | 0.82 | ALDH1A1 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL31238899 | 0.82 | ALOX15 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL634973 | 0.82 | ALOX15 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| Butane SCHEMBL11358505 | 0.80 | ALDH1A1 (0.46) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL2485258 | 0.79 | ALOX15 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL14403293 | 0.79 | ALOX15 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL556528 | 0.78 | ALDH1A1 (0.48) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL1299895 | 0.78 | CYP4F2 (0.44) | ALOX15CYP4F2CYP4A11ALDH1A1PKM | |
| SCHEMBL28388180 | 0.78 | ALOX15 (0.52) | ALOX15CYP4F2CYP4A11ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101072760-B | Malonamide derivatives as gamma-secretase inhibitors for the treatment of Alzheimer's disease | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-28 | — | — | CN | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2009-07-30 | — | — | US | disclosed |
| CN-101410378-A | Malonamide derivatives as gamma secretase inhibitors | HOFFMANN LA ROCHE (CH) | 2009-04-15 | — | — | CN | disclosed |
| EP-1945620-A2 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2008-07-23 | — | — | EP | disclosed |
| CN-101072760-A | Malonamide derivatives as gamma-secretase inhibitors for the treatment of Alzheimer's disease | HOFFMANN LA ROCHE (CH) | 2007-11-14 | — | — | CN | disclosed |
| WO-2007056366-A2 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056366-A2 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | IRM LLC (BM) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192203-A1 | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS | PPARG, PPARA, PPARD | ALOX15 436/4885CYP4F2 1191/4885CYP4A11 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.