Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.37 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5539507 | 0.83 | CYP3A4 (0.34) | CYP3A4TSHRMAPK1TDP1PDE2A | |
| SCHEMBL97195 | 0.82 | IDO1 (0.47) | NOTUMIDO1HTR3EHTR3BHTR3A | |
| SCHEMBL2046047 | 0.78 | NOTUM (0.37) | NOTUMDAOTSHR | |
| SCHEMBL15263626 | 0.78 | STK17B (0.37) | IDO1GRM4 | |
| SCHEMBL16958432 | 0.77 | CYP3A4 (0.37) | CYP3A4TSHRMAPK1TDP1PDE2A | |
| SCHEMBL29403188 | 0.76 | TSHR (0.62) | NOTUMKMODAOCYP3A4TSHR | |
| SCHEMBL107751 | 0.76 | TSHR (0.62) | NOTUMKMODAOCYP3A4TSHR | |
| SCHEMBL5504987 | 0.75 | PTPN1 (0.46) | — | |
| SCHEMBL3789260 | 0.74 | PDE2A (0.56) | KMODAOTSHRPDE2AMRGPRX4 | |
| SCHEMBL364144 | 0.74 | HSD11B1 (0.44) | NOTUMKMODAOCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109678872-B | Bisbenzylisoquinoline compound and preparation method and application thereof | 山东师范大学 | 2020-09-29 | — | — | CN | claimed |
| CN-110577563-B | Fluorine-containing compound, preparation method thereof and application thereof in preparation of antitumor drugs | 山东师范大学 | 2020-09-04 | — | — | CN | claimed |
| CN-110577563-A | Fluorine-containing compound, preparation method thereof and application thereof in preparation of antitumor drugs | 山东师范大学 | 2019-12-17 | — | — | CN | claimed |
| EP-2532663-B1 | Naphthalenetetracarboxylic acid derivatives and their use as semiconductors | BASF SE (DE) | 2016-03-16 | — | — | EP | claimed |
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | claimed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | claimed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | claimed |
| EP-2532663-A1 | Naphthalenecarboxylic acid derivatives and their use as semiconductors | BASF SE (DE) | 2012-12-12 | — | — | EP | claimed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | claimed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | claimed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | claimed |
| CN-109678871-B | Method for preparing bisbenzylisoquinoline compounds | 山东师范大学 | 2020-09-29 | — | — | CN | disclosed |
| CN-109678872-B | Bisbenzylisoquinoline compound and preparation method and application thereof | 山东师范大学 | 2020-09-29 | — | — | CN | disclosed |
| CN-110577563-B | Fluorine-containing compound, preparation method thereof and application thereof in preparation of antitumor drugs | 山东师范大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-109776553-B | Fuhexine and preparation method and application thereof | 山东师范大学 | 2020-05-29 | — | — | CN | disclosed |
| US-20070259475-A1 | METHOD FOR PRODUCING ORGANIC FIELD-EFFECT TRANSISTORS | BASF AKTIENGESELLSCHAFT (DE) | 2007-11-08 | — | — | US | disclosed |
| WO-2007093643-A1 | FLUORINATED RYLENETETRACARBOXYLIC ACID DERIVATIVES AND USE THEREOF | BASF SE (DE) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007074137-A1 | NAPHTHALENETETRACARBOXYLIC ACID DERIVATIVES AND THEIR USE AS SEMICONDUCTORS | BASF SE (DE) | 2007-07-05 | — | — | WO | disclosed |
| EP-0122488-A1 | Bis-(piperazinyl- or homopiperazinyl)-alkanes | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | NOTUM 2496/4885KMO 964/4885DAO 2687/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | NOTUM 2496/4885KMO 964/4885DAO 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.