Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047981 | 0.83 | TRPV4 (0.51) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 | |
| SCHEMBL25976983 | 0.80 | L3MBTL1 (0.68) | SMN1; SMN2L3MBTL1MAPK1GAAKMT2A | |
| SCHEMBL5960683 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1MAPK1GAAKMT2A | |
| SCHEMBL12180426 | 0.78 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 | |
| SCHEMBL30514814 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRGAAKMT2APKM | |
| SCHEMBL1790129 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRGAAKMT2APKM | |
| SCHEMBL2650962 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 | |
| SCHEMBL16316790 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 | |
| SCHEMBL4572998 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 | |
| SCHEMBL10710253 | 0.76 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1TSHRPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1500657-B1 | Substituted pyrazoles as P38 kinase inhibitors | SEARLE LLC (US) | 2007-09-19 | — | — | EP | disclosed |