Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14411400 | 0.83 | SMN1; SMN2 (0.65) | SMN1; SMN2L3MBTL1GLATSHRPOLB | |
| SCHEMBL38243330 | 0.79 | TRPV4 (0.73) | TRPV4SMN1; SMN2L3MBTL1TSHRPOLB | |
| SCHEMBL29482636 | 0.79 | L3MBTL1 (0.64) | TRPV4SMN1; SMN2L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL750886 | 0.79 | TRPV4 (0.73) | TRPV4SMN1; SMN2L3MBTL1TSHRPOLB | |
| SCHEMBL407215 | 0.79 | L3MBTL1 (0.64) | TRPV4SMN1; SMN2L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL5012595 | 0.79 | SMN1; SMN2 (0.59) | TRPV4SMN1; SMN2L3MBTL1GLATSHR | |
| SCHEMBL739940 | 0.79 | KMT2A (0.60) | TRPV4SMN1; SMN2L3MBTL1TSHRPOLB | |
| SCHEMBL25976983 | 0.79 | L3MBTL1 (0.68) | SMN1; SMN2L3MBTL1GLAMAPK1GAA | |
| SCHEMBL47015 | 0.78 | SMN1; SMN2 (0.64) | TRPV4SMN1; SMN2GLATSHRKDM4E | |
| SCHEMBL13100208 | 0.78 | TRPV4 (0.51) | TRPV4SMN1; SMN2L3MBTL1GLATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008129288-A2 | DISULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |