Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290173 | 0.83 | CA2 (0.54) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL7290168 | 0.80 | ALDH1A1 (0.43) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL13589485 | 0.79 | ENPP2 (0.48) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL483015 | 0.79 | HSD11B1 (0.48) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL14468048 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2POLBHSD11B1ALDH1A1MAPT | |
| SCHEMBL14341655 | 0.78 | SMN1; SMN2 (0.61) | ALOX15HSD17B10SMN1; SMN2POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL27809979 | 0.78 | HSD11B1 (0.47) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL3067655 | 0.78 | HSD11B1 (0.50) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL13588738 | 0.75 | SMN1; SMN2 (0.45) | ALOX15HSD17B10SMN1; SMN2POLBHSD11B1 | |
| SCHEMBL8953650 | 0.73 | SMN1; SMN2 (0.50) | ALOX15HSD17B10SMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084625-A9 | NOVEL COMPOUNDS AND METHODS FOR INHIBITING P53 ACTIVITY | SINAI SCHOOL MEDICINE (US) | 2007-09-13 | — | — | WO | disclosed |