Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | MAT2A | P31153 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MDM4 | O15151 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257070 | 1.00 | KCNH2 (0.51) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL14604966 | 0.86 | NFE2L2 (0.48) | KCNH2MAT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL14416284 | 0.86 | ALDH1A1 (0.44) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL10322856 | 0.86 | ALDH1A1 (0.44) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL257115 | 0.86 | ALDH1A1 (0.44) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL16067619 | 0.79 | KCNH2 (0.56) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL17458649 | 0.79 | KCNH2 (0.56) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL5176004 | 0.77 | RAB9A (0.44) | KCNH2MAT2ATDP1SMN1; SMN2HPGD | |
| SCHEMBL20091021 | 0.77 | HSD11B1 (0.38) | KCNH2MAT2ATDP1LMNAKMT2A | |
| SCHEMBL19053751 | 0.76 | KCNH2 (0.47) | KCNH2MAT2ATDP1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271270-B2 | High affinity small molecule C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-09-18 | — | — | US | disclosed |