Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14422201 | 0.87 | KMT2A (0.45) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL14422198 | 0.85 | TRPV1 (0.48) | NPC1RAB9ATRPV1NR3C1 | |
| SCHEMBL5217205 | 0.77 | MMP2 (0.56) | SMN1; SMN2LMNAALDH1A1POLBMEN1 | |
| SCHEMBL14422196 | 0.76 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL14422199 | 0.76 | TAAR1 (0.46) | POLBMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL5215090 | 0.75 | TAAR1 (0.45) | POLBMEN1KMT2AKDM4E | |
| SCHEMBL9942086 | 0.73 | LMNA (0.57) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL14422264 | 0.73 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL11031455 | 0.70 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL21348783 | 0.68 | FADS1 (0.51) | NPC1RAB9ASMN1; SMN2EGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7265138-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1818333-A1 | Vanilloid receptor ligands and their use in treatments | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |