Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flomoxef. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | CMA1 | P23946 | 18/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flomoxef SCHEMBL49438 | 1.00 | PTGS1 (0.57) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL65125 | 0.99 | PTGS1 (0.57) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL27661462 | 0.99 | PTGS1 (0.57) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL30531854 | 0.93 | HSD17B10 (0.58) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL30716855 | 0.93 | HSD17B10 (0.58) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL27896310 | 0.92 | PTGS1 (0.51) | PTGS1CMA1HSD17B10TDP1 | |
| SCHEMBL30515648 | 0.86 | CMA1 (0.60) | PTGS1CMA1 | |
| Flomoxef SCHEMBL30515667 | 0.82 | PTGS1 (0.44) | PTGS1CMA1HSD17B10TDP1 | |
| Flomoxef SCHEMBL18065040 | 0.78 | NR1I2 (0.58) | PTGS1HSD17B10TDP1 | |
| Flomoxef SCHEMBL2563269 | 0.78 | ABCB11 (0.53) | PTGS1CMA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007105253-A2 | PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES | CARTHESIA S.A.S. DI EMANUELA MIGLIAVACCA & C. (IT) | 2007-09-20 | — | — | WO | disclosed |