Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.92 |
| ▸ | HPGD | P15428 | 4/20 | 0.92 |
| ▸ | GAA | P10253 | 2/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.92 |
| ▸ | MEN1 | O00255 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | HTT | P42858 | 3/20 | 0.81 |
| ▸ | CRHBP | P24387 | 1/20 | 0.81 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | METAP2 | P50579 | 1/20 | 0.65 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6404885 | 0.87 | TSHR (0.72) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL14426675 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL6403463 | 0.79 | CYP3A4 (0.73) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL27952226 | 0.78 | MAPK1 (0.71) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL31411197 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL6406121 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL28670789 | 0.77 | SIRT2 (0.66) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL4208096 | 0.77 | SMN1; SMN2 (0.66) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL16409996 | 0.76 | SIRT2 (1.00) | SMN1; SMN2HPGDGAAMAPK1MEN1 | |
| SCHEMBL27809458 | 0.76 | ALDH1A1 (0.63) | SMN1; SMN2HPGDGAAMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-08-23 | — | — | US | disclosed |
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | LCK, PTPN6, PTPN22 | SMN1; SMN2 3437/4885HPGD 3910/4885GAA 4124/4885 |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | LCK, PTPN6, PTPN22 | SMN1; SMN2 3437/4885HPGD 3910/4885GAA 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.