Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12604562 | 0.82 | HTT (0.45) | HTTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL10424339 | 0.80 | LMNA (0.42) | HTTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL10424396 | 0.80 | L3MBTL1 (0.42) | HTTTSHRLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10424394 | 0.78 | LMNA (0.41) | HTTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL10424341 | 0.78 | LMNA (0.45) | HTTTSHRLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL14433874 | 0.77 | F2 (0.48) | ALDH1A1PHGDHALDH2MGLLL3MBTL1 | |
| SCHEMBL14434063 | 0.76 | MGLL (0.41) | ALDH1A1PHGDHMGLLRAB9A | |
| SCHEMBL14434111 | 0.74 | HSD11B1 (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL84372 | 0.74 | TSHR (0.62) | HTTTSHRLMNAPOLBSMN1; SMN2 | |
| SCHEMBL19446412 | 0.73 | LMNA (0.43) | HTTTSHRLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007087204-A2 | HETEROCYCLES AS NICOTINIC ACID RECEPTOR AGONISTS FOR THE TREATMENT OF DYYSLIPIDEMIA | SCHERING CORPOORATION (US) | 2007-08-02 | — | — | WO | disclosed |