Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 11/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434882 | 0.91 | CXCR2 (0.42) | CXCR2CXCR1GPR27FABP4FABP5 | |
| SCHEMBL14434490 | 0.90 | POLB (0.48) | CXCR2CXCR1AVPR2GPR27FABP4 | |
| SCHEMBL14434874 | 0.88 | CXCR2 (0.46) | CXCR2CXCR1ALDH1A1POLBMETAP2 | |
| SCHEMBL14434073 | 0.87 | ALDH1A1 (0.39) | CXCR2AVPR2GPR27ALDH1A1HSD17B10 | |
| SCHEMBL14434886 | 0.86 | CXCR2 (0.40) | CXCR2GPR27FABP4FABP5SIRT6 | |
| SCHEMBL14434870 | 0.85 | IDH1 (0.39) | CXCR2AVPR2GPR27ALDH1A1MEN1 | |
| SCHEMBL14434070 | 0.84 | ALDH1A1 (0.45) | CXCR2GPR27ALDH1A1MEN1MAPT | |
| SCHEMBL14434503 | 0.84 | CXCR2 (0.44) | CXCR2CXCR1AVPR2GPR27FABP4 | |
| SCHEMBL14434072 | 0.83 | ALDH1A1 (0.47) | CXCR2ALDH1A1POLBMETAP2MEN1 | |
| SCHEMBL14434879 | 0.83 | L3MBTL1 (0.43) | CXCR2ALDH1A1POLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |