Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 10/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434879 | 0.93 | L3MBTL1 (0.43) | CXCR2ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14434072 | 0.93 | ALDH1A1 (0.47) | CXCR2METAP2ALDH1A1LMNAMAPT | |
| SCHEMBL14434071 | 0.92 | HTT (0.44) | CXCR2METAP2ALDH1A1LMNAMAPT | |
| SCHEMBL5322006 | 0.91 | PTGDR2 (0.40) | CXCR2ALDH1A1MAPTPTGDR2 | |
| SCHEMBL14434876 | 0.91 | CASP6 (0.41) | CXCR2ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL5321346 | 0.90 | PTPN5 (0.45) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL14435097 | 0.90 | POLB (0.50) | CXCR2CXCR1METAP2ALDH1A1LMNA | |
| SCHEMBL14434883 | 0.88 | CXCR2 (0.43) | CXCR2CXCR1METAP2ALDH1A1MAPT | |
| SCHEMBL5320272 | 0.88 | CXCR2 (0.49) | CXCR2ALDH1A1LMNAHTTPTGDR2 | |
| SCHEMBL14434886 | 0.87 | CXCR2 (0.40) | CXCR2ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091140-A1 | SUBSTITUTED PHENYLSULFAMOYL COMPOUNDS AS PPAR AGONISTS | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |