Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734174 | 0.80 | ALDH1A1 (0.54) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL763824 | 0.74 | MMP1 (0.56) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL14400848 | 0.74 | MMP1 (0.56) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL755094 | 0.71 | ALDH1A1 (0.49) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL13489665 | 0.70 | KMT2A (0.53) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 | |
| SCHEMBL26848353 | 0.68 | L3MBTL1 (0.62) | ALDH1A1L3MBTL1TSHRMEN1KMT2A | |
| SCHEMBL3609715 | 0.68 | HSD11B1 (0.57) | ALDH1A1HTTMAPTRAB9AHSD11B1 | |
| SCHEMBL3609710 | 0.68 | HSD11B1 (0.57) | ALDH1A1HTTMAPTRAB9AHSD11B1 | |
| SCHEMBL5654242 | 0.68 | MMP1 (0.56) | ALDH1A1LMNASMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL5112289 | 0.67 | HSD11B1 (0.55) | ALDH1A1HTTLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |