SCHEMBL14435477

SCHEMBL14435477

CC(=O)OCC(=O)Nc1c(C)c(C(=O)Cl)c(C)c(C(=O)N(C)CC(O)CO)c1C

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.33
USP2 O75604 1/20 0.31
HPGD P15428 1/20 0.31
ALDH1A1 P00352 1/20 0.31
PKM P14618 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709499 0.84 LMNA (0.64) LMNASMN1; SMN2USP2HPGDALDH1A1
SCHEMBL14435485 0.81 SMN1; SMN2 (0.45) LMNASMN1; SMN2USP2HPGDALDH1A1
SCHEMBL7523494 0.76 LMNA (0.49) LMNASMN1; SMN2ALDH1A1PKM
SCHEMBL13955980 0.75 LMNA (0.66) LMNAALDH1A1
SCHEMBL10454668 0.74 LMNA (0.52) LMNASMN1; SMN2USP2HPGDALDH1A1
SCHEMBL25813475 0.74 LMNA (0.41) LMNA
SCHEMBL13247449 0.74 LMNA (0.47) LMNASMN1; SMN2USP2HPGDALDH1A1
SCHEMBL29088010 0.73 LMNA (0.76) LMNAHPGD
SCHEMBL13327904 0.73 LMNA (0.60) LMNA
SCHEMBL13873487 0.71 LMNA (0.64) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007094683-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2007-08-23 WO disclosed