SCHEMBL1443571

SCHEMBL1443571

Cc1cc(C(=O)CN)ccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
TAS1R2 Q8TE23 1/20 0.46
MCL1 Q07820 1/20 0.44
KMO O15229 3/20 0.42
MAOA P21397 1/20 0.42
MAOB P27338 1/20 0.42
TSHR P16473 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MGAM O43451 1/20 0.40
AMY1A P0DUB6 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
HDAC8 Q9BY41 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17823285 0.98 CYP1A2 (0.50) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL27778655 0.83 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL2278168 0.83 CYP3A4 (0.52) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL2097486 0.83 GSK3B (0.53) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL30022982 0.82 KMO (0.59) KMOTSHRHDAC8HDAC3HDAC4
SCHEMBL747018 0.82 KMO (0.59) KMOTSHRHDAC8HDAC3HDAC4
SCHEMBL3269069 0.82 HTT (0.50) TSHRKMT2ASMN1; SMN2GAA
SCHEMBL7620529 0.81 GSK3B (0.55) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL2075296 0.81 CYP1A2 (0.51) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3
SCHEMBL243504 0.81 GSK3B (0.55) CYP1A2CYP3A4CYP2C9CYP2C19TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3230274-B1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS Bayer Pharma AG (DE) 2019-01-30 EP disclosed
US-10023539-B2 Aryl-cyanoguanidine compounds BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-07-17 US disclosed
US-10023539-B2 Aryl-cyanoguanidine compounds BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-07-17 US disclosed
US-20180099937-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-04-12 US disclosed
US-20180099937-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-04-12 US disclosed
US-20170342034-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-11-30 US disclosed
US-20170342034-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-11-30 US disclosed
US-9650362-B2 Inhibitors PROBIODRUG AG (DE) 2017-05-16 US disclosed
WO-2016091845-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-06-16 WO disclosed
US-20160039795-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2016-02-11 US disclosed
US-9173885-B2 Inhibitors PROBIODRUG AG (DE) 2015-11-03 US disclosed
EP-2475428-B1 HETEROCYLCIC DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2015-07-01 EP disclosed
US-20140065095-A1 NOVEL INHIBITORS VIVORYON THERAPEUTICS N.V. (DE) 2014-03-06 US disclosed
US-8486940-B2 Inhibitors PROBIODRUG AG (DE) 2013-07-16 US disclosed
EP-2475428-A1 HETEROCYLCIC DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE Probiodrug AG (DE) 2012-07-18 EP disclosed
US-20110092501-A1 NOVEL INHIBITORS PROBIODRUG AG (DE) 2011-04-21 US disclosed
WO-2011029920-A1 HETEROCYLCIC DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2011-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110092501-A1 NOVEL INHIBITORS GLUL, QPCT, GLS CYP1A2 839/4885CYP3A4 1152/4885CYP2C9 504/4885
US-20160039795-A1 NOVEL INHIBITORS GLUL, QPCT, GLS CYP1A2 839/4885CYP3A4 1152/4885CYP2C9 504/4885
US-10023539-B2 Aryl-cyanoguanidine compounds SMYD2, SETD2, SMYD3 CYP1A2 2285/4885CYP3A4 4240/4885CYP2C9 2421/4885
US-20140065095-A1 NOVEL INHIBITORS GLUL, QPCT, GLS CYP1A2 839/4885CYP3A4 1152/4885CYP2C9 504/4885
US-20180099937-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS SMYD2, SETD2, SMYD3 CYP1A2 2325/4885CYP3A4 4167/4885CYP2C9 2382/4885
US-20170342034-A1 NOVEL ARYL-CYANOGUANIDINE COMPOUNDS SMYD2, SETD2, SMYD3 CYP1A2 2330/4885CYP3A4 4147/4885CYP2C9 2542/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.