Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425306 | 0.88 | MAOB (0.70) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL712779 | 0.88 | ALDH1A1 (0.59) | MAOBSMN1; SMN2ALDH1A1L3MBTL1SLC6A2 | |
| SCHEMBL5042654 | 0.87 | FFAR1 (0.66) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL19599654 | 0.85 | FFAR1 (0.51) | MAOBFFAR1FFAR4SMN1; SMN2ALDH1A1 | |
| SCHEMBL1228881 | 0.84 | PTGS1 (0.56) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL68570 | 0.83 | ALOX5 (0.69) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL20442640 | 0.82 | NR1H4 (0.60) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL5033197 | 0.81 | FFAR1 (0.77) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| Ethylene SCHEMBL11248134 | 0.81 | ALOX5 (0.66) | MAOBALOX5PTGS1PTGS2NR4A1 | |
| SCHEMBL13886196 | 0.81 | PLA2G4B (0.60) | SMN1; SMN2CYP1A2HIF1AHDAC6PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253318-B2 | Benzyloxy derivatives as MAOB inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |