Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 3/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109133 | 0.94 | VCP (0.35) | HDAC1HDAC8VCPTDP1RHEB | |
| SCHEMBL6972304 | 0.91 | HSP90B1 (0.37) | HDAC1HDAC8VCPTDP1HSP90B1 | |
| SCHEMBL14439829 | 0.90 | VCP (0.36) | HDAC1HDAC8VCPTDP1RHEB | |
| SCHEMBL6972409 | 0.89 | VCP (0.35) | VCPTDP1SLC5A2DHODHTP53 | |
| SCHEMBL6965896 | 0.88 | VCP (0.36) | HDAC1HDAC8VCPTDP1SLC5A2 | |
| SCHEMBL14439828 | 0.88 | TDP1 (0.40) | VCPTDP1SLC5A2TSHRDHODH | |
| SCHEMBL6966496 | 0.87 | VCP (0.37) | VCPTDP1SLC5A2TSHRADAMTS5 | |
| SCHEMBL6973959 | 0.87 | VCP (0.35) | VCPTDP1SLC5A2ADAMTS5MMP2 | |
| SCHEMBL14439841 | 0.86 | VCP (0.36) | VCPTDP1SLC5A2TSHRADAMTS5 | |
| SCHEMBL6960981 | 0.86 | TLR8 (0.33) | TDP1RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |