Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5853114 | 0.95 | TDP1 (0.37) | TDP1VCPTP53MAPTRECQL | |
| SCHEMBL14439857 | 0.93 | DHODH (0.39) | TDP1TP53MAPTDHODHSMN1; SMN2 | |
| SCHEMBL6957630 | 0.93 | DHODH (0.39) | TDP1TP53MAPTDHODHSMN1; SMN2 | |
| SCHEMBL6966496 | 0.93 | VCP (0.37) | TDP1VCPTP53MAPTSLC5A2 | |
| SCHEMBL6974703 | 0.92 | TDP1 (0.41) | TDP1VCPTP53MAPTTACR1 | |
| SCHEMBL14439829 | 0.92 | VCP (0.36) | TDP1VCPTP53MAPTRECQL | |
| SCHEMBL6965896 | 0.92 | VCP (0.36) | TDP1VCPTP53MAPTRECQL | |
| SCHEMBL14439841 | 0.92 | VCP (0.36) | TDP1VCPTP53MAPTSLC5A2 | |
| SCHEMBL6960433 | 0.91 | TDP1 (0.34) | TDP1VCPTP53MAPTKMT2A | |
| SCHEMBL6966431 | 0.90 | TP53 (0.37) | TDP1VCPTP53MAPTALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |