Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479091 | 0.87 | AKR1B1 (0.41) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL13675039 | 0.86 | LMNA (0.39) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL13672777 | 0.82 | AKR1B1 (0.41) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL13672778 | 0.80 | AKR1B1 (0.43) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL4479556 | 0.79 | CENPE (0.44) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL14441029 | 0.79 | AKR1B1 (0.36) | AKR1B1WDR5MAPK1 | |
| SCHEMBL4473972 | 0.79 | AKR1B1 (0.41) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL4490682 | 0.78 | CENPE (0.40) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL4487792 | 0.76 | THRB (0.46) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL4495602 | 0.76 | AKR1B1 (0.40) | LMNASMN1; SMN2HTTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070179196-A1 | Hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179196-A1 | Hiv integrase inhibitors | REV1, TYMP, POLR2H | LMNA 4273/4885SMN1; SMN2 4492/4885HTT 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.