Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | POLB | P06746 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.79 |
| ▸ | LMNA | P02545 | 7/20 | 0.79 |
| ▸ | APAF1 | O14727 | 3/20 | 0.79 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.79 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.79 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.79 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MPI | P34949 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981834 | 1.00 | MEN1 (1.00) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL12819453 | 0.89 | GAA (0.80) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL1444105 | 0.88 | MAPT (1.00) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL1443318 | 0.88 | GAA (0.79) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL11961913 | 0.88 | GAA (0.79) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL11961914 | 0.88 | MAPT (1.00) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL13745582 | 0.88 | MAPT (1.00) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL11901247 | 0.81 | MAPT (0.71) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL11961918 | 0.81 | MAPT (0.71) | MEN1KMT2APOLBGAAMAPT | |
| SCHEMBL23837656 | 0.80 | MAPT (0.78) | MEN1KMT2APOLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473486-B2 | PYRIMIDINES AS HEPCIDINE ANTAGONISTS | VIFOR INT AG (CH) | 2021-09-22 | — | — | EP | disclosed |
| EP-2473486-B1 | PYRIMIDINES AS HEPCIDINE ANTAGONISTS | VIFOR INT AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
| EP-2473486-A1 | NOVEL PYRIMIDINE AND TRIAZINE HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2012-07-11 | — | — | EP | disclosed |
| WO-2011026835-A1 | NOVEL PYRIMIDINE AND TRIAZINE HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | HAMP, DHPS, SLC40A1 | MEN1 4413/4885KMT2A 3797/4885POLB 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.