Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.51 |
| ▸ | LOX | P28300 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875123 | 1.00 | ALOX5 (0.51) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL8876780 | 1.00 | ALOX5 (0.51) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL13619726 | 0.84 | ALOX5 (0.49) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL1809436 | 0.81 | ALOX5 (0.51) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL1444769 | 0.79 | ALOX5 (0.55) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9502722 | 0.79 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL79534 | 0.79 | ALOX5 (0.54) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9601261 | 0.78 | MEN1 (0.38) | HDAC6 | |
| SCHEMBL9824749 | 0.76 | ALOX5 (0.53) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL4361286 | 0.76 | ALOX5 (0.51) | ALOX5CYP1A2PTGESLMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036680-A2 | IMPROVED PROCESS FOR THE PREPARATION OF (±)-1-(1-BENZO[B]THIEN-2-YLETHYL)-1-HYDROXYUREA | MSN LABORATORIES LIMITED (IN) | 2011-03-31 | — | — | WO | claimed |
| EP-0708753-A4 | SYNTHESIS OF ACID ADDITION SALTS OF HYDROXYLAMINES | SMITHKLINE BEECHAM CORP (US) | 1996-10-02 | — | — | EP | claimed |
| EP-0708753-A1 | SYNTHESIS OF ACID ADDITION SALTS OF HYDROXYLAMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-05-01 | — | — | EP | claimed |
| WO-1995002574-A1 | SYNTHESIS OF ACID ADDITION SALTS OF HYDROXYLAMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-26 | — | — | WO | claimed |
| WO-2020035729-A1 | TOPICAL OLEAGINOUS COMPOSITIONS | DR. REDDY'S LABORATORIES LTD. (IN) | 2020-02-20 | — | — | WO | disclosed |
| US-9670176-B2 | Process for the preparation of zileuton | STRIDES SHASUN LIMITED (IN) | 2017-06-06 | — | — | US | disclosed |
| US-9670176-B2 | Process for the preparation of zileuton | STRIDES SHASUN LIMITED (IN) | 2017-06-06 | — | — | US | disclosed |
| US-20160376251-A1 | Process for the Preparation of Zileuton | STRIDES SHASUN LIMITED (IN) | 2016-12-29 | — | — | US | disclosed |
| US-8933250-B2 | Process for the preparation of N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea | FARMAK, A.S. (CZ) | 2015-01-13 | — | — | US | disclosed |
| US-8933250-B2 | Process for the preparation of N-(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea | FARMAK, A.S. (CZ) | 2015-01-13 | — | — | US | disclosed |
| US-20110184189-A1 | PROCESS FOR THE PREPARATION OF N-(1-BENZO[B]THIEN-2-YLETHYL)-N-HYDROXYUREA | FARMAK, A.S. (CZ) | 2011-07-28 | — | — | US | disclosed |
| US-20110184189-A1 | PROCESS FOR THE PREPARATION OF N-(1-BENZO[B]THIEN-2-YLETHYL)-N-HYDROXYUREA | FARMAK, A.S. (CZ) | 2011-07-28 | — | — | US | disclosed |
| EP-0708753-A1 | SYNTHESIS OF ACID ADDITION SALTS OF HYDROXYLAMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002574-A1 | SYNTHESIS OF ACID ADDITION SALTS OF HYDROXYLAMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-26 | — | — | WO | disclosed |
| US-5250565-A | Must incorporate a metabolically cleavable leaving group; pro-drugs; administering to mammals | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0279263-B1 | INDOLE, BENZOFURAN, BENZOTHIOPHENE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0416609-A2 | Benzo[b]thiophene-containing lipoxygenase-inhibiting compounds | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4992464-A | Bronchodilator, antiinflammatory, antiarthritic, antiallergenic agents | ABBOTT LABORATORIES (US) | 1991-02-12 | — | — | US | disclosed |
| US-4873259-A | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0279263-A2 | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376251-A1 | Process for the Preparation of Zileuton | CYP2B6, UGT1A6, CYP2A6 | ALOX5 124/4885CYP1A2 35/4885PTGES 1385/4885 |
| US-20110184189-A1 | PROCESS FOR THE PREPARATION OF N-(1-BENZO[B]THIEN-2-YLETHYL)-N-HYDROXYUREA | NUDT1, SLC29A1, SLC9A1 | ALOX5 2404/4885CYP1A2 614/4885PTGES 1990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.