Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 9/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 9/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 9/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 9/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20821412 | 0.87 | PDK1 (0.50) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL28528551 | 0.83 | ALDH1A1 (0.58) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL9321672 | 0.81 | PDK1 (0.51) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL29824473 | 0.80 | PDK1 (0.50) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL4344024 | 0.80 | PDK1 (0.70) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL1542594 | 0.80 | PDK1 (0.50) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL11117971 | 0.80 | ALDH1A1 (0.46) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL3926897 | 0.79 | PDK1 (0.35) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL12758952 | 0.79 | PDK1 (0.44) | PDK1PDK2PDK3PDK4TP53 | |
| SCHEMBL8626954 | 0.77 | PDK1 (0.66) | PDK1PDK2PDK3PDK4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | ISTITUTO DI RICERCHE DI BIOLOGIA DI MOLECULOARE P. ANGELETTI SPA (IT) | 2007-07-19 | — | — | US | disclosed |
| US-20070072911-A1 | Indoles and azaindoles as antiviral agents | AVOLIO SALVATORE | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072911-A1 | Indoles and azaindoles as antiviral agents | IDO1, IDO2, NAT1 | PDK1 4424/4885PDK2 3189/4885PDK3 2815/4885 |
| US-20070167447-A1 | Indole acetamides as inhibitors of the hepatitis c virus ns5b polymerase | IDO1, NAT1, AANAT | PDK1 4587/4885PDK2 3257/4885PDK3 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.