Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228179 | 0.88 | ADRB2 (0.77) | POLBALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL14456712 | 0.86 | ALDH1A1 (0.79) | POLBALDH1A1TSHRLMNAKMT2A | |
| SCHEMBL8223177 | 0.82 | ADRB2 (0.90) | ALDH1A1TSHRLMNAKDM4EKMT2A | |
| SCHEMBL14456710 | 0.82 | ADRB2 (0.67) | POLBALDH1A1TSHRKMT2AADRB2 | |
| SCHEMBL25138819 | 0.81 | POLB (0.72) | POLBALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL8228226 | 0.81 | ADRB2 (0.69) | POLBALDH1A1TSHRKMT2AADRB2 | |
| SCHEMBL14456711 | 0.80 | ADRB2 (0.65) | POLBALDH1A1TSHRKDM4EKMT2A | |
| SCHEMBL14456952 | 0.80 | POLB (0.78) | POLBALDH1A1TSHRLMNAKMT2A | |
| SCHEMBL14456886 | 0.80 | CYP3A4 (0.69) | ALDH1A1TSHRKDM4EKMT2AADRB2 | |
| SCHEMBL8223191 | 0.80 | FAAH (0.82) | TSHRKDM4EADRB2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |