Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14456960 | 0.86 | CHRM1 (0.62) | KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14456952 | 0.80 | POLB (0.78) | ALDH1A1SMN1; SMN2TSHRKMT2ACYP3A4 | |
| SCHEMBL14456957 | 0.79 | TGM2 (0.50) | ALDH1A1TSHRKMT2ACYP3A4LMNA | |
| SCHEMBL14456950 | 0.79 | CYP2C19 (0.60) | ALDH1A1SMN1; SMN2TSHRKMT2ACYP3A4 | |
| SCHEMBL14456956 | 0.77 | CNR1 (0.69) | ALDH1A1TSHRLMNANPSR1 | |
| SCHEMBL14456892 | 0.77 | MEN1 (0.63) | ALDH1A1TSHRMEN1KMT2ACYP3A4 | |
| SCHEMBL14456974 | 0.76 | CYP3A4 (0.53) | ALDH1A1MAPK1TSHRCYP3A4LMNA | |
| SCHEMBL24754220 | 0.75 | TSHR (0.71) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL14456954 | 0.75 | ALDH1A1 (0.55) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL14456748 | 0.75 | KMT2A (0.73) | ALDH1A1SMN1; SMN2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238688-B2 | Piperidine compounds | SCHERING CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |