Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822777 | 0.87 | ALOX5 (0.61) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL12298123 | 0.86 | RAB9A (0.62) | ALOX5CYP1A2MEN1KMT2ANPC1 | |
| SCHEMBL28340413 | 0.86 | MEN1 (0.68) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL12298054 | 0.84 | CYP1A1 (0.82) | ALOX5CYP1A1CYP1A2CYP1B1SMN1; SMN2 | |
| SCHEMBL1820964 | 0.83 | NPC1 (0.71) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL28340370 | 0.83 | ALOX5 (0.69) | ALOX5CYP1A1CYP1B1MEN1KMT2A | |
| SCHEMBL12298188 | 0.83 | VCP (0.58) | ALOX5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12298371 | 0.81 | KDM1A (0.53) | ALOX5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12297672 | 0.80 | ALOX5 (0.89) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 | |
| SCHEMBL12298201 | 0.80 | NPC1 (0.52) | ALOX5CYP1A1CYP1A2CYP1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244739-B2 | Compounds and uses thereof in modulating amyloid beta | TORREYPINES THERAPEUTICS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244739-B2 | Compounds and uses thereof in modulating amyloid beta | TORREYPINES THERAPEUTICS, INC. (US) | 2007-07-17 | — | — | US | disclosed |