Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.83 |
| ▸ | ARG2 | P78540 | 4/20 | 0.52 |
| ▸ | ARG1 | P05089 | 3/20 | 0.52 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.50 |
| ▸ | OTC | P00480 | 1/20 | 0.50 |
| ▸ | GLUL | P15104 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1825922 | 1.00 | GSR (0.83) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL103555 | 1.00 | GSR (0.83) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11803679 | 1.00 | GSR (0.83) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11798743 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11670724 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL5444480 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11799059 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11671036 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL11801574 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC | |
| Lysine SCHEMBL8143571 | 0.98 | GSR (0.80) | GSRARG2ARG1RNPEPOTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130211071-A1 | METHOD FOR MAKING ALPHA-AMINO-EPSILON-CAPROLACTAM USING MIXED SUPER CRITICAL FLUIDS | INVENTURE RENEWABLES, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| EP-1761487-B1 | SYNTHESIS OF CAPROLACTAM FROM LYSINE | UNIV MICHIGAN STATE (US) | 2013-08-07 | — | — | EP | disclosed |
| US-8367819-B2 | Synthesis of caprolactam from lysine | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-02-05 | — | — | US | disclosed |
| US-20120142886-A1 | Synthesis of Caprolactam From Lysine | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2012-06-07 | — | — | US | disclosed |
| US-20110190488-A1 | Methods of Making Cyclic Amide Monomers and Related Derivatives | Amyris, Inc. | 2011-08-04 | — | — | US | disclosed |
| US-7977450-B2 | Synthesis of caprolactam from lysine | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2318373-A1 | METHODS OF MAKING CYCLIC AMIDE MONOMERS, AND RELATED DERIVATIVES AND METHODS | Draths Corporation (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2301919-A1 | Synthesis of caprolactam from lysine | Board of Trustees of Michigan State University (US) | 2011-03-30 | — | — | EP | disclosed |
| WO-2010011967-A1 | METHODS OF MAKING CYCLIC AMIDE MONOMERS, AND RELATED DERIVATIVES AND METHODS | DRATHS CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| US-20090005532-A1 | SYNTHESIS OF CAPROLACTAM FROM LYSINE | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-01-01 | — | — | US | disclosed |
| US-7399855-B2 | Synthesis of caprolactam from lysine | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2008-07-15 | — | — | US | disclosed |
| US-20070149777-A1 | Synthesis of caprolactam from lysine | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-06-28 | — | — | US | disclosed |
| US-20070128339-A1 | Nutrient modified food composition | MANKOVITZ ROY J | 2007-06-07 | — | — | US | disclosed |
| EP-1761487-A1 | SYNTHESIS OF CAPROLACTAM FROM LYSINE | Board of Trustees of Michigan State University (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123669-A1 | SYNTHESIS OF CAPROLACTAM FROM LYSINE | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149777-A1 | Synthesis of caprolactam from lysine | JMJD6, KDM6A, PHYKPL | GSR 4771/4885ARG2 1343/4885ARG1 222/4885 |
| US-20120142886-A1 | Synthesis of Caprolactam From Lysine | JMJD6, KDM6A, PHYKPL | GSR 4781/4885ARG2 1308/4885ARG1 215/4885 |
| US-20110190488-A1 | Methods of Making Cyclic Amide Monomers and Related Derivatives | NAAA, PHYKPL, RIMKLA | GSR 4694/4885ARG2 271/4885ARG1 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.