Sugi Predict

Sugi Predict / Compounds / SCHEMBL1446375

SCHEMBL1446375

SCHEMBL1446375

CC(C)(C)OC(=O)N1CC[C@H](O)[C@H]1CO[Si](C)(C)C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.39
▸ TSHR P16473 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ L3MBTL1 Q9Y468 2/20 0.36
▸ CHRM2 P08172 1/20 0.35
▸ CHRM1 P11229 1/20 0.35
▸ CHRM3 P20309 1/20 0.35
▸ FKBP1A P62942 1/20 0.35
▸ LMNA P02545 1/20 0.34
▸ USP2 O75604 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ HSD17B10 Q99714 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1446373 1.00 ALDH1A1 (0.39) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL30743030 0.92 ALDH1A1 (0.45) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL22969745 0.87 ALDH1A1 (0.39) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL31603357 0.86 ALDH1A1 (0.36) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL31603214 0.86 ALDH1A1 (0.36) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL7869194 0.85 ALDH1A1 (0.38) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL29211166 0.83 ALDH1A1 (0.46) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL31603219 0.82 ALDH1A1 (0.41) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL15185040 0.82 ALDH1A1 (0.36) ALDH1A1TSHRMEN1KMT2AL3MBTL1
SCHEMBL20942571 0.82 ALDH1A1 (0.37) ALDH1A1TSHRMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7910743-B2 Compounds, compositions and methods CYTOKINETICS, INC. (US) 2011-03-22 — — US disclosed
US-7910743-B2 Compounds, compositions and methods CYTOKINETICS, INC. (US) 2011-03-22 — — US disclosed
US-20090324511-A1 Compounds, Compositions and Methods CYTOKINETICS, INC. 2009-12-31 — — US disclosed
US-20090324511-A1 Compounds, Compositions and Methods CYTOKINETICS, INC. 2009-12-31 — — US disclosed
US-7538223-B2 Compounds, compositions and methods CYTOKINETICS, INC. (US) 2009-05-26 — — US disclosed
US-7538223-B2 Compounds, compositions and methods CYTOKINETICS, INC. (US) 2009-05-26 — — US disclosed
US-20070066626-A1 Compounds, compositions and methods CYTOKINETICS, INCORPORATED 2007-03-22 — — US disclosed
US-20070066626-A1 Compounds, compositions and methods CYTOKINETICS, INCORPORATED 2007-03-22 — — US disclosed
US-6310095-B1 INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE UNIVERSITY OF PITTSBURGH 2001-10-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090324511-A1 Compounds, Compositions and Methods TNNI3, TNNC1, TNNT2 ALDH1A1 4381/4885TSHR 4548/4885MEN1 4344/4885
US-20070066626-A1 Compounds, compositions and methods TNNI3, TNNC1, TNNT2 ALDH1A1 4381/4885TSHR 4548/4885MEN1 4344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.