Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29494159 | 0.79 | TRPA1 (0.54) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL3873734 | 0.79 | TRPA1 (0.54) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL18884370 | 0.77 | TRPA1 (0.52) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL22593340 | 0.77 | TRPA1 (0.52) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL5454938 | 0.77 | KCNMA1 (0.49) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL12451042 | 0.76 | GAA (0.55) | TP53TDP1GAAHSD17B10ALDH1A1 | |
| SCHEMBL23097222 | 0.74 | RAPGEF4 (0.38) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL18761588 | 0.74 | ALOX15 (0.48) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL1259060 | 0.74 | CYP3A4 (0.50) | TRPA1TP53TDP1KCNMA1GAA | |
| SCHEMBL19113279 | 0.74 | TRPA1 (0.48) | TRPA1TP53TDP1KCNMA1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075567-A1 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-05 | — | — | WO | disclosed |