Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469167 | 0.91 | ALDH1A1 (0.41) | TSHRKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL14469451 | 0.88 | TSHR (0.46) | TSHRHPGDKDM4EKMT2AMEN1 | |
| SCHEMBL14469560 | 0.79 | ALDH1A1 (0.47) | TSHRKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8223234 | 0.79 | CYP3A4 (0.49) | TSHRKMT2AMEN1 | |
| SCHEMBL8230536 | 0.79 | CYP3A4 (0.49) | TSHRKMT2AMEN1 | |
| SCHEMBL14469569 | 0.78 | ALDH1A1 (0.47) | TSHRKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL14469551 | 0.77 | KDM4E (0.48) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL14469477 | 0.77 | KMT2A (0.58) | TSHRKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL14469473 | 0.77 | KMT2A (0.43) | TSHRHPGDKDM4EKMT2AMEN1 | |
| SCHEMBL14469461 | 0.76 | HDAC1 (0.46) | TSHRKDM4EKMT2AMEN1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |