Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497295 | 0.94 | ALDH1A1 (0.35) | ALDH1A1KDM4EMAPTNPSR1LMNA | |
| SCHEMBL5497297 | 0.94 | ALDH1A1 (0.35) | ALDH1A1KDM4EMAPTNPSR1LMNA | |
| SCHEMBL5497269 | 0.81 | NOTUM (0.36) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL5497277 | 0.81 | NOTUM (0.36) | ALDH1A1KDM4EMAPTSMN1; SMN2NPC1 | |
| SCHEMBL5491912 | 0.78 | KDM4E (0.35) | ALDH1A1KDM4EMAPTNPSR1LMNA | |
| SCHEMBL5491918 | 0.78 | KDM4E (0.35) | ALDH1A1KDM4EMAPTNPSR1LMNA | |
| SCHEMBL9039166 | 0.73 | CYP4A11 (0.52) | ALDH1A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL9343047 | 0.72 | CYP4A11 (0.53) | ALDH1A1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL8982245 | 0.71 | TDP1 (0.38) | ALDH1A1KDM4EMAPTNPSR1LMNA | |
| SCHEMBL9343689 | 0.71 | CYP4A11 (0.52) | ALDH1A1KDM4EMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167377-A1 | Inhibitors of glycinamide ribonucleotide transformylase | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167377-A1 | Inhibitors of glycinamide ribonucleotide transformylase | TYMS, NMT2, NMT1 | ALDH1A1 726/4885KDM4E 1825/4885MAPT 2783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.