Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039166 | 0.83 | CYP4A11 (0.52) | TDP1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9343047 | 0.82 | CYP4A11 (0.53) | TDP1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9343689 | 0.81 | CYP4A11 (0.52) | TDP1NPC1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL11212513 | 0.77 | LOXL2 (0.46) | TDP1HTTNPC1RAB9AKDM4E | |
| SCHEMBL28831138 | 0.74 | NPC1 (0.51) | TDP1NPC1CASP1RAB9ASMN1; SMN2 | |
| SCHEMBL9794868 | 0.74 | MEN1 (0.52) | TDP1LMNAMAPTALDH1A1CA12 | |
| SCHEMBL5491912 | 0.73 | KDM4E (0.35) | TDP1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5491918 | 0.73 | KDM4E (0.35) | TDP1HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9794854 | 0.72 | CA1 (0.42) | TDP1HTTNPC1RAB9ALMNA | |
| SCHEMBL8982266 | 0.72 | CA1 (0.40) | TDP1HTTNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0452660-B1 | L-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-05-29 | — | — | EP | disclosed |
| EP-0452660-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-10-23 | — | — | EP | disclosed |
| US-5013738-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-07 | — | — | US | disclosed |