Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343047 | 0.96 | CYP4A11 (0.53) | CYP4A11CYP4F2LOXL2HTTKDM4E | |
| SCHEMBL9343689 | 0.95 | CYP4A11 (0.52) | CYP4A11CYP4F2LOXL2KDM4EALDH1A1 | |
| SCHEMBL11212513 | 0.84 | LOXL2 (0.46) | CYP4A11CYP4F2LOXL2HTTKDM4E | |
| SCHEMBL10419232 | 0.83 | PPARA (0.46) | KDM4EALDH1A1HPGDTP53CYP1A2 | |
| SCHEMBL8982245 | 0.83 | TDP1 (0.38) | CYP4A11CYP4F2LOXL2HTTKDM4E | |
| SCHEMBL10480005 | 0.82 | CYP4A11 (0.49) | CYP4A11CYP4F2LOXL2HTTKDM4E | |
| SCHEMBL9850083 | 0.79 | DAO (0.34) | CYP4A11CYP4F2HTTKDM4EALDH1A1 | |
| SCHEMBL10420226 | 0.79 | PPARA (0.44) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL10419972 | 0.79 | PPARA (0.44) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL9050346 | 0.78 | CYP4A11 (0.61) | CYP4A11CYP4F2LOXL2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0325343-B1 | L-glutamic acid derivatives | UNIV PRINCETON (US) | 1994-06-22 | — | — | EP | disclosed |
| US-4871743-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0325343-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-26 | — | — | EP | disclosed |