Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469562 | 0.87 | L3MBTL1 (0.47) | KDM4EALDH1A1L3MBTL1MEN1TSHR | |
| SCHEMBL14469477 | 0.86 | KMT2A (0.58) | KDM4EALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL14469549 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1MEN1TSHR | |
| SCHEMBL14469190 | 0.85 | CYP3A4 (0.48) | MEN1TSHRKMT2A | |
| SCHEMBL14469285 | 0.84 | L3MBTL1 (0.44) | KDM4EALDH1A1L3MBTL1MEN1TSHR | |
| SCHEMBL14469460 | 0.84 | KMT2A (0.51) | KDM4EALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL14469449 | 0.84 | KMT2A (0.53) | KDM4EALDH1A1L3MBTL1MEN1TSHR | |
| SCHEMBL14469568 | 0.82 | S1PR5 (0.52) | ALDH1A1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14469456 | 0.82 | SMN1; SMN2 (0.50) | KDM4EALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL14469475 | 0.82 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |