Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469812 | 0.92 | KMT2A (0.38) | GPBAR1PKMADORA2BAKR1B1KMT2A | |
| SCHEMBL14469705 | 0.82 | TDP1 (0.42) | PKMADORA2BKMT2ASLC6A2SLC6A3 | |
| SCHEMBL14469684 | 0.81 | PRKCZ (0.42) | KMT2ASLC6A2SLC6A3TDP1TSHR | |
| SCHEMBL14469714 | 0.80 | TSHR (0.45) | GPBAR1KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL14469745 | 0.80 | ALDH1A1 (0.43) | GPBAR1PKMKMT2AMEN1SLC6A2 | |
| SCHEMBL20830732 | 0.66 | TDP1 (0.58) | KMT2AMEN1SLC6A2SLC6A3TDP1 | |
| SCHEMBL24117922 | 0.64 | TDP1 (0.54) | KMT2ASLC6A2SLC6A3TDP1TSHR | |
| SCHEMBL22245235 | 0.63 | TDP1 (0.54) | GPBAR1KMT2ASLC6A2SLC6A3TDP1 | |
| SCHEMBL25910700 | 0.63 | TDP1 (0.46) | GPBAR1PKMKMT2ASLC6A2SLC6A3 | |
| SCHEMBL31448243 | 0.63 | ALDH1A1 (0.50) | PKMKMT2ASLC6A2SLC6A3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686983-B1 | USE OF PENTADIENOIC ACID DERIVATES FOR TREATEMENT OF HYPERURICEMIA | MERCK PATENT GMBH (DE) | 2007-07-11 | — | — | EP | disclosed |