Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469684 | 0.87 | PRKCZ (0.42) | TSHRALDH1A1PRKCZSLC6A2SLC6A3 | |
| SCHEMBL14469705 | 0.87 | TDP1 (0.42) | TSHRALDH1A1LMNAPRKCZSLC6A2 | |
| SCHEMBL14469714 | 0.85 | TSHR (0.45) | TSHRGPBAR1ALDH1A1PRKCZSLC6A2 | |
| SCHEMBL14469745 | 0.82 | ALDH1A1 (0.43) | TSHRGPBAR1ALDH1A1LMNASLC6A2 | |
| SCHEMBL15080317 | 0.69 | TSHR (0.41) | TSHRGPBAR1ALDH1A1LMNAPRKCZ | |
| SCHEMBL24117922 | 0.66 | TDP1 (0.54) | TSHRALDH1A1LMNASLC6A2SLC6A3 | |
| SCHEMBL31189998 | 0.65 | POLB (0.56) | TSHRALDH1A1LMNASLC6A2SLC6A3 | |
| SCHEMBL27413685 | 0.65 | POLB (0.56) | TSHRALDH1A1LMNASLC6A2SLC6A3 | |
| SCHEMBL30806015 | 0.65 | ALDH1A1 (0.54) | TSHRGPBAR1ALDH1A1LMNASLC6A2 | |
| SCHEMBL29138237 | 0.65 | ALDH1A1 (0.54) | TSHRGPBAR1ALDH1A1LMNASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686983-B1 | USE OF PENTADIENOIC ACID DERIVATES FOR TREATEMENT OF HYPERURICEMIA | MERCK PATENT GMBH (DE) | 2007-07-11 | — | — | EP | disclosed |