Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.43 |
| ▸ | PTAFR | P25105 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.34 |
| ▸ | DRD1 | P21728 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTR3A | P46098 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474694 | 0.86 | HRH1 (0.43) | HRH1PTAFRDRD3DRD2SETD7 | |
| SCHEMBL14473932 | 0.77 | HRH1 (0.62) | HRH1PTAFRDRD3DRD2CHRM2 | |
| SCHEMBL20978787 | 0.71 | HRH1 (0.53) | HRH1PTAFRDRD3DRD2CHRM2 | |
| SCHEMBL20978776 | 0.70 | HRH1 (0.47) | HRH1PTAFRDRD3DRD2CHRM2 | |
| SCHEMBL20978944 | 0.69 | HRH1 (0.45) | HRH1PTAFRDRD3DRD2CHRM2 | |
| SCHEMBL12910009 | 0.66 | CHRNB2 (0.50) | HRH4TDP1ALDH1A1HTT | |
| SCHEMBL12910031 | 0.65 | CHRNB2 (0.51) | HRH1PTAFRHRH4TDP1ALDH1A1 | |
| SCHEMBL11486348 | 0.65 | DRD3 (0.59) | HRH1DRD3DRD2SETD7CHRM2 | |
| SCHEMBL9035699 | 0.65 | SETD7 (0.60) | HRH1DRD3DRD2SETD7CHRM2 | |
| SCHEMBL11779252 | 0.64 | DRD2 (0.60) | HRH1DRD3DRD2SETD7CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727919-B1 | BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO LTD (CN) | 2019-05-08 | — | — | EP | disclosed |
| US-10022362-B2 | Anti-allergy benzocycloheptathiophene derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10022362-B2 | Anti-allergy benzocycloheptathiophene derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD (CN) | 2018-07-17 | — | — | US | disclosed |
| US-20160166563-A1 | Anti-Allergy Benzocycloheptathiophene Derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD (CN) | 2016-06-16 | — | — | US | disclosed |
| US-20160166563-A1 | Anti-Allergy Benzocycloheptathiophene Derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD (CN) | 2016-06-16 | — | — | US | disclosed |
| US-9296731-B2 | Anti-allergy benzocycloheptathiophene derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD. (CN) | 2016-03-29 | — | — | US | disclosed |
| US-9296731-B2 | Anti-allergy benzocycloheptathiophene derivatives | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD. (CN) | 2016-03-29 | — | — | US | disclosed |
| US-20140135361-A1 | ANTI-ALLERGY BENZOCYCLOHEPTATHIOPHENE DERIVATIVES | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD. (CN) | 2014-05-15 | — | — | US | disclosed |
| US-20140135361-A1 | ANTI-ALLERGY BENZOCYCLOHEPTATHIOPHENE DERIVATIVES | FUJIAN MINDONG REJUVENATION PHARMACEUTICAL CO., LTD. (CN) | 2014-05-15 | — | — | US | disclosed |
| EP-2727919-A1 | BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS | Fujian Mindong Rejuvenation Pharmaceutical Co., Ltd. (CN) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013000406-A1 | BENZOCYCLOHEPTANETHIOPHENE DERIVATIVES FOR ANTI-ALLERGIC REACTIONS | LIN TONGJUN (CN) | 2013-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166563-A1 | Anti-Allergy Benzocycloheptathiophene Derivatives | NR1H4, TST, CYP7A1 | HRH1 14/4885PTAFR 1811/4885DRD3 2282/4885 |
| US-20140135361-A1 | ANTI-ALLERGY BENZOCYCLOHEPTATHIOPHENE DERIVATIVES | TST, HRH1, ABCB11 | HRH1 2/4885PTAFR 1472/4885DRD3 3497/4885 |
| US-10022362-B2 | Anti-allergy benzocycloheptathiophene derivatives | NR1H4, TST, CYP7A1 | HRH1 14/4885PTAFR 1811/4885DRD3 2282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.